Appendix

1

Specification

1

2

Supporting journals:

Lactosucrose has many scientific evidences on the following benefits:

2.1

2.1.1

Effect of Lactosucrose on the Feeling of Defecation and the Condition of Feces in Adult Females (1995)

2.1.2

4G-β-Galactosylscurose（ラクトスクロース）摂取が女子学生の便通に及ぼす影響 (1994)

Lactosucrose for defection and constipation

2.1.3

Effects of instant soybean paste containing galactosylsucrose on defecation and intestinal microflora in male and female students (2002)

2.1.4

Effect of oral lactosucrose supplementation on human enteric oxalate-degrading bacteria

ヒト腸内シュウ酸分解菌に対する乳果オリゴ糖経口投与の効果 (2006)

2.1.6

生物工学　第88巻(japan journals)「整腸・Ca 吸収促進Wの効果」乳果オリゴ糖の開発

Intestinal benefits and promoting Ca absorption by Lactosucrose.

2.1.7

Effect of Administration of Lactosucrose on Abdominal Symptoms in Lactose intolerant

2.1.8

Effect of Lactosucrose on the Feeling of Defecation and the Condition of Feces in Adult Females

2.2

2.2.1

Effect of lactosucrose on bone in weanling rats (1999)

2.2.2

Effect of single and two-week repeated ingestion of granules containing lactosucrose on fecal flora properties (2005)

2.2.3

Long-term administration of 4G-beta-D-galactosylsucrose (lactosucrose) Enhances intestinal calcium absorption in young women: A randomized, placebo-controlled 96-wk study (2006)

2.3

2.3.1

Effect of dietary lactosucrose (4G-beta-D-galactosylsucrose) on the intestinal immune functions in mice (2007)

2.3.2

Effects of Dietary Lactosucrose (4G-_-D-galactosylsucrose) on the IgE Response in Mice (2007)

2.3.3

Influenza Prevention

2.4

Lactosucrose Inhibits Body Fat Accumulation in Rats by Decreasing Intestinal Lipid Absorption (2009)

3

Safety study:

Lactosucrose is a very safe food ingredient.

3.1 Acute oral toxicity-lactosucrose

3.3 List of FOSHU (Foods for Specified Health Use, Japan)

Lactosucrose (Lacto-fructo oligosaccharide) is listed in FOSHU, and many LS products are for pregnant women and children.